How Scream Cream Makes Menopause Sex Better

Johnson hopes this launch marks a shift toward closing the gender desire gap.

O-mazing + Estradiol Vaginal Cream = the perfect combo for improved sexual health

“Daré’s commitment to both clinical integrity and timely access ensures women who need it don’t have to wait to benefit from this innovation.”1 DARE to PLAY sildenafil cream now available for pre-order by prescription: First evidence-based topical arousal cream for women begins commercial rollout in select states via 503B outsourcing facility. Preliminary efficacy of topical sildenafil cream for the treatment of female sexual arousal disorder: A randomized controlled trial. "With women, it has been viewed as more complicated .. but it's not." Today, doctors can begin prescribing a first-of-its-kind arousal cream for women. Daré Bioscience, a biotech company focused solely on women’s health innovations, launched DARE to PLAY™, a cream to improve women’s sexual health and desire. “Men were very loud about the fact that it was so critical to their sexual function and sexual activity to be able to have an erection.

• The effectiveness of Viagra cream depends on skin absorption.
• It is sometimes promoted as a natural alternative.
• Possible benefits include reduced frequency of side effects.
• Scientific evidence supporting its use is limited.
• Users should be wary of false advertising claims.
• Some formulations may contain unsafe or unregulated ingredients.
• Proper use involves cleaning the application area thoroughly.
• The cream should be applied as per product instructions.
• Do not exceed recommended dosage to avoid irritation.
• Keep out of reach of children and pets.

With women, it has been viewed as more complicated … but it’s not,” says Johnson.

Product	Dosage	Quantity + Bonus	Price
Viagra Generic	100mg	60 + 4 Pills	96.36€ 91.77€	Buy
Viagra Generic	150mg	270 + 10 Pills	326.61€ 311.06€	Buy
Viagra Oral Jelly	100mg	220 + 18 Sachets	562.28€ 535.50€	Buy
Viagra Generic	200mg	30 + 2 Pills	83.07€ 79.11€	Buy
Viagra Generic	150mg	10 Pills	36.73€ 34.98€	Buy
Viagra Oral Jelly	100mg	90 + 8 Sachets	258.02€ 245.73€	Buy
Viagra Generic	100mg	360 + 10 Pills	330.21€ 314.49€	Buy
Viagra Oral Jelly	100mg	21 Sachets	78.66€ 74.91€	Buy
Viagra Soft Tabs	100mg	10 Pills	36.93€ 35.17€	Buy
Viagra Generic	100mg	120 + 6 Pills	149.50€ 142.38€	Buy
Viagra Original	100mg	12 Pills	72.54€ 69.09€	Buy

“It’s really not that much more complicated.

How the Cream Works: Arousal, Nitric Oxide, and Touch

“The Role of Local Vaginal Estrogen for Treatment of Vaginal Atrophy in Postmenopausal Women.” Menopause, vol. “Vaginal Estrogen Use and Chronic Disease Risk in the Nurses' Health Study.” Menopause, vol. DARE to PLAY is a topical sildenafil cream enhancing female arousal, available in select states as a compounded product while awaiting FDA approval. Clinical trials showed improved arousal sensation scores, though not statistically significant compared to placebo, with significant benefits in a subset of women with FSAD. Daré Bioscience said the sildenafil cream’s availability will expand to other states throughout December 2025 and early 2026.

Vaginal Itching and Menopause: Causes and Relief

DARE to PLAY, a proprietary topical arousal cream designed to enhance genital blood flow and arousal response in women, can now be prescribed in select states, manufacturer Daré Bioscience, Inc announced in a news release.1 “When Viagra [sildenafil citrate] was approved in 1998, it revolutionized sexual medicine for men. But for women, comparable progress on enhancing the natural arousal sensations has stalled for nearly 3 decades,” said Sabrina Martucci Johnson, President and CEO of Daré Bioscience, in the news release. “We believe DARE to PLAY represents a long overdue correction, giving women an option to reconnect with their own bodies, their pleasure, and their confidence, using science that finally recognizes their needs.”1 As the company continues the process to seek FDA approval of the sildenafil cream formulation, it is making the cream available in the form of a Section 503B compounded product. Although the sildenafil cream is manufactured “in an outsourcing facility subject to FDA inspection and under current Good Manufacturing Practice regulations,” Daré Bioscience noted that compounded drugs are not FDA approved or evaluated by the agency for “safety, effectiveness, or quality.”1 DARE to PLAY is currently available for prescription for pre-order in Connecticut, Florida, Indiana, Missouri, New Jersey, Oregon, Pennsylvania, Rhode Island, and Utah. Daré Bioscience said the sildenafil cream’s availability will expand to other states throughout December 2025 and early 2026.1 DARE to PLAY has been evaluated in several studies, including a phase 2b randomized controlled trial (NCT04948151), the results of which were published in Obstetrics & Gynecology. There’s desire [and] there’s arousal, just like in men.” Johnson, who has worked in women’s health innovation for over two decades, hopes this product not only serves women’s sexual health but also normalizes it as an integral pillar of their whole health.

Wisp Care Team

SST completes Phase I trial of SST-6006 to treat erectile dysfunction in men. Alprostadil cream in the treatment of erectile dysfunction: clinical evidence and experience. Scoping review exploring advancements in topical agent therapies for erectile dysfunction. Alpostadil in cream — a new option of treating erectile dysfunctions in diabetes. Could the drug used to treat erectile dysfunction help women who have difficulties with arousal?

Other Literature Sources

It’s a question that sexual medicine researchers have puzzled over since at least the late 1990s, when the Food and Drug Administration approved sildenafil, known as Viagra, for men. Doctors prescribe sildenafil off-label to some female patients, either in the form of low doses of the pill or as a topical cream made by compounding pharmacies. Telehealth companies, like Alloy and Wisp, sell the creams on their platforms. Daré, a pharmaceutical company, is in the process of seeking approval from the F.D.A. for its topical sildenafil cream, which it plans to market specifically to women. In the meantime, DARE to PLAY joins a sparse field of prescription arousal products for women.

Ingredient	Concentration (%)	Function	Source
Sildenafil Citrate	2.5	Main active ingredient	Pharmaceutical lab
Emulsifiers	1.5	Improve texture	Chemical suppliers
Preservatives	0.2	Extend shelf life	Chemical suppliers
Moisturizers	3.0	Skin hydration	Cosmetic manufacturers

Sprout Pharmaceuticals’ Addyi, a pill to treat hypoactive sexual desire disorder in premenopausal women, faced an uphill battle before receiving FDA approval in 2015.

The Alloy Promise

Yet the research, including a study from Daré out today, suggests that if the drug is at all effective at increasing arousal in women, it’s only likely to do so for a small subset. During menopause and perimenopause, many women experienced diminished or less intense orgasms. Topical sildenafil increases blood flow to wherever you apply it (in this case, your clitoris or labia), and increased blood flow leads to increased sensation. Sildenafil: Increases blood flow, stimulates natural lubrication, and heightens physical sensations leading to a stronger, more fulfilling orgasm. In a 2002 study, sildenafil was found to be effective in enhancing vaginal engorgement in healthy premenopausal women.

Control of lipolysis by natriuretic peptides and cyclic GMP

We've found that it works well in perimenopausal and menopausal women as well! Pentoxifylline: Influences changes in blood flow and improves blood flow to genital tissue. One bottle of each, a 3-month supply, billed at $169.95. Menopause doesn’t mean saying goodbye to your sex life. Estrogen loss can cause dry vaginal skin, painful sex, and a dip in desire. As Dr.

Science-backed ingredients

Estradiol Vaginal Cream restores moisture and improves elasticity. O-mazing Cream stimulates lubrication and increases blood flow, leading to more fulfilling orgasms. Together, they make sex feel good again! You’ll have unlimited access to your menopause-specialized doctor with your sexual health product subscription. “Management of Genitourinary Syndrome of Menopause in Women with or at High Risk for Breast Cancer.” Menopause, vol.

Let's do it.

Nurnberg HG, Hensley PL, Heiman JR, Croft HA, Debattista C, Paine S. Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial. “The 2020 Genitourinary Syndrome of Menopause Position Statement of the North American Menopause Society.” Menopause, vol. Schoen C, Bachmann G. Sildenafil citrate for female viagra medicine sexual arousal disorder: a future possibility? Sadaf Lodhi, a sex counselor and board-certified OB-GYN, told Flow Space, women have long felt obligated to normalize low libido and painful sex. Ten years ago, no one was talking about libido as much.

• Viagra cream is a topical treatment designed for erectile dysfunction.
• It contains the active ingredient sildenafil.
• Applied directly to the skin for quick absorption.
• Typically used before sexual activity for increased blood flow.
• Often marketed as an alternative to oral tablets.
• May have fewer systemic side effects than pills.
• Application areas usually include the inner thigh or genitals.
• Effectiveness can vary depending on individual response.
• Needs to be applied about 15-30 minutes prior to sex.
• Not suitable for people allergic to sildenafil or similar drugs.

[Women] don’t need to settle for sex being painful or a decreased libido if it’s bothering them,” she says.

• Viagra cream is part of a broader category of topical ED treatments.
• It offers an alternative for men who dislike oral medications.
• The product may be flavored or designed to mask medicinal taste.
• It can be used with other sexual enhancement products cautiously.
• Some users prefer creams for their discreet nature.
• Clinical research is ongoing into topical PDE5 inhibitors.
• Side effects may include skin rash or allergic reaction.
• Realistic expectations are important for satisfaction.
• Price varies based on brand, formulation, and availability.
• Always purchase from reputable sources to ensure quality.

“To want sex is to have sex worth wanting.

Publication types

In that study, 200 women with female sexual arousal disorder (FSAD) were randomly assigned to receive the sildenafil cream or placebo cream. The co-primary efficacy end points included change from baseline to week 12 in the Arousal Sensation domain of the Sexual Function Questionnaire (SFQ28), as well as question 14 of the Female Sexual Distress Scale—Desire, Arousal, Orgasm (FSDS-DAO).2 Greater improvement in SFQ28 Arousal Sensation domain scores was observed in patients receiving sildenafil cream, although “there were no statistically significant differences between sildenafil and placebo cream users in the coprimary and secondary efficacy end points,” wrote the authors. The investigators also conducted an exploratory post hoc analysis evaluating a subset of the intention-to-treat population who had a diagnosis of FSDD with or without concomitant decreased desire. In this subset, significant increases in SFQ28 Arousal Sensation domain score were seen vs the placebo group. These patients also had a higher mean improvement in SFQ28 Desire and Orgasm domain scores, as well as significantly decreased sexual distress and interpersonal difficulties as assessed by FSDS-DAO questions 3, 5, and 10.2 “As more women speak openly about their sexual health, the need for research-backed solutions has never been greater,” said Irwin Goldstein, MD, director of San Diego Sexual Medicine in California viagra 100mg and a founder of the International Society for the Study of Women’s Sexual Health in the news release. I always say to my patients, ‘if you’re not experiencing pleasure with intimacy, then you’re not going to want it.’” Johnson says that

• Viagra cream's popularity is growing among alternative therapies.
• It is often advertised online without regulatory approval.
• Users should research product ingredients before use.
• Topical application may reduce some systemic side effects.
• Temporary side effects include flushing and headache.
• Proper technique in application influences effectiveness.
• Avoid applying to mucous membranes or broken skin.
• Expect some changes in sensation in the applied area.
• Do not share or reuse leftover cream.
• Discuss potential interactions with healthcare providers.

successfully creating the formulation, ensuring it could work in 10 minutes, was integral to getting the cream to market to serve women’s needs.

Conclusion: Healing, Not Just Heat

The product, which is now available in some states through prescription, is made with the same active ingredient as Viagra: sildenafil. Viagra was FDA-approved in 1998 to treat erectile dysfunction in men, and nearly thirty years later, momentum to create similar products for women has lagged far behind. At least one in five women will experience low libido or struggle with arousal during sex; for women in midlife, low libido is more common amid hormonal fluctuations. “We knew from existing research that the same active ingredient in Viagra could have similar benefits for women, but when taken as a pill, it caused unwanted side effects,” CEO of Daré Bioscience Sabrina Johnson tells Flow Space. “So, we asked a simple question: what if we could deliver it differently?” The topical cream formulation works by increasing blood flow before a sexual activity by opening and relaxing blood vessels in the clitoris and vulva, where the cream is applied.