
Sildenafil (Revatio) can cause some serious health issues.
*All brands listed are the registered trademarks of their respective owners and are not trademarks of Hetero Labs Limited. Sildenafil (Revatio) is used to treat pulmonary arterial hypertension or PAH (high blood pressure in the lungs) in people ages 1 year and older. It works as a phosphodiesterase 5 (PDE5) inhibitor to help improve your ability to exercise and slow PAH from getting worse. This medication is available as a tablet and oral suspension that you take by mouth. There's also an injection that's given through the vein in a hospital setting.
In general, the dose is taken three times per day. Side effects include headache, flushing, and muscle pain. Sildenafil (Revatio) has both brand-name and generic versions. Pulmonary arterial hypertension or PAH (high blood pressure in the lungs) Sildenafil (Revatio) is a phosphodiesterase 5 (PDE5) inhibitor. It blocks a protein in the body called PDE5. This risk may be even higher canadian sildenafil citrate for certain groups. If this worries you, talk to your doctor or pharmacist about other options. Risk factors: Certain heart problems Low fluids in the body (dehydration) Low blood pressure at rest Also taking erectile dysfunction medications Also taking blood pressure medications Also taking nitrates like nitroglycerin Sildenafil (Revatio) can cause your blood pressure to drop. It can make you feel dizzy, tired, or lightheaded. This side effect is usually mild and doesn't last long. Tell your prescriber and pharmacist about all the medications you take. You're at risk of having this side effect if you also take other medications that lower blood pressure.
You can't take sildenafil (Revatio) if you also take nitrates like nitroglycerin.
This is because of the risk of a severe drop in blood pressure.
| Side Effect | Incidence Rate | Severity | Commonality | Notes |
|---|---|---|---|---|
| Headache | High | Mild to moderate | Common | Usually resolves quickly |
| Flushing | Moderate | Mild | Common | Reddening of face and neck |
| Dizziness | Moderate | Mild to moderate | Common | Especially when standing up quickly |
| Vision Changes | Low | Mild to moderate | Less common | Blurred vision or light sensitivity |
After you take sildenafil (Revatio), sit down for the first few minutes to help prevent dizziness. Get emergency help if you feel like you might pass out, feel confused, have a fast heartbeat, or have chest pain. These can be serious signs of very low blood pressure. Sildenafil (Revatio) isn't recommended if you have pulmonary vascular occlusive disease (PVOD). This is a rare condition that affects the blood flow between your lungs and heart. Sildenafil (Revatio) hasn't been studied in people with PVOD. But it's possible that it can make this condition worse. Tell your care team if you have any shortness of breath, a cough that doesn't go away, tiredness, or chest pain.
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These could be signs of fluid buildup in your lungs, and your care team should check you for PVOD.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: pain or tenderness around the eyes and cheekbones diarrhea or stomach cramps (severe or continuing) numbness or tingling of the hands, legs, or feet redness, soreness, swelling, or bleeding of the gums sensation of motion, usually whirling, either of one's self or of one's surroundings sexual problems in men (continuing), including failure to experience a sexual orgasm sores in the mouth and on the lips Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
A first-choice option for treating PAH Approved for children with PAH as young as 1 year old Available as an oral liquid for people who have trouble swallowing pills Can cause headaches and low blood pressure Can't take if you also take nitrates for sildenafil citrate tablets 50 mg your heart Not recommended if you also take erectile dysfunction medications Take sildenafil (Revatio) 3 times a day every day so the medication works as best as it can to help your PAH. For example, you can take it in the morning, mid-afternoon, and in the evening. Separate your doses by a few hours, like 4 to 6 hours apart. Taking them too close together can put you at risk of side effects, like headache and low blood pressure. You can take sildenafil (Revatio) with or without food. Risk factors: PAH due to connective tissue disease Also taking the blood thinner called warfarin This is more likely to happen if you take the blood thinner warfarin.
They'll also give you a dosing cup, spoon, or oral syringe to help you measure out your dose. Before taking a dose, shake the bottle well for at least 10 seconds. Use a medication dosing cup, spoon, or oral syringe to measure out your dose. They might not be accurate, so you might take the wrong dose. There are two options to store the oral suspension.
You can keep it at room temperature (up to 86ºF). Or, you can put it in the refrigerator (though be sure not to let it freeze). Once you get the oral suspension from the pharmacy, the medication is good for 60 days. The pharmacist usually writes the expiration date on the label on the bottle. Throw the medication away after this date, even if there's still medication left over. Tell your care team if you start getting nosebleeds often.
Don't break, crush, or chew the tablet. If you can't swallow them well, talk to your prescriber. They might be able to switch you to the oral suspension of medication. Sildenafil (Revatio) can make your blood pressure drop and make you feel dizzy for a short time after taking it. Then when you feel better, stand up slowly and hold onto something strong to help you up.
If dizziness doesn't go away or if you have a racing heart, let your care team know. Don't change your dose or stop taking sildenafil (Revatio) unless your prescriber tells you to. This is important even if you start to feel better. Stopping too soon can cause your symptoms to come back and can worsen your PAH. Tell your healthcare team about all the medications you take or plan to take. And get medical attention if you have a nosebleed that you can't stop. Risk factors: History of eye problems, including a "crowded" optic disc Although rare, reports of eye damage might be linked to taking PDE5 inhibitors like sildenafil (Revatio). This eye damage is called non-arteritic anterior ischemic optic neuropathy (NAION). It happens when there's poor blood flow to the nerves in the eye. Symptoms include sudden loss of vision in one eye, eye pain, and headache.
This relaxes the blood vessels that go from your heart to your lungs. When these blood vessels relax, more blood can flow through. This lowers the amount of work your heart needs to do to pump blood to your lungs to get oxygen for your body. The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following. Low blood pressure: dizziness, lightheadedness, nausea, blurry vision, tiredness, fainting, fast heart rate, chest pain, confusion Vision loss or other sudden vision changes Priapism: erection that lasts longer than 4 hours, pain during an erection Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: burning feeling in the chest or stomach burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decrease in amount of urine or the frequency of urination dizziness or lightheadedness, especially when getting up suddenly from a lying or sitting position dryness, redness, scaling, or peeling of the skin increase in the size of the pupil redness, burning, or swelling of the eyes redness, itching, or tearing of the eyes seeing shades of colors differently than before swelling of the face, hands, feet, or lower legs unusual feeling of burning or stinging of the skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. It might lead to permanent vision loss if not treated. Before you start sildenafil (Revatio), tell your prescriber about your full medical history. This medication isn't recommended for people with an eye problem called retinitis pigmentosa. The risk of this eye damage might also be higher if an eye specialist has told you that you have a "crowded" optic disc. If you have sudden vision changes or lose vision in one or both eyes while taking sildenafil (Revatio), go to the emergency room or call an eye specialist right away. They can check out what's going on. Some people who took sildenafil (Revatio) reported hearing loss.
This includes prescriptions, over-the-counter medications, vitamins, and supplements. Sildenafil (Revatio) can interact with many medications. Some are for blood pressure, enlarged prostate, or erectile dysfunction. Your care team can check for harmful interactions and adjust your medications if needed. Don't take nitrate medications, such as nitroglycerin (Nitrostat), with sildenafil (Revatio).
This can make your blood pressure drop to dangerously low levels. Get medical help right away if you have sudden changes in vision or hearing while taking sildenafil (Revatio). Also get emergency help if you have an erection that lasts for more than 4 hours or is very painful. These problems can be serious and should get checked out. More tips for the 10 mg/mL oral suspension of sildenafil (Revatio): The pharmacy will prepare the oral suspension when you pick up the medication. This can sometimes happen with ringing in the ears (tinnitus) and dizziness. It isn't clear whether these effects are related to the medication or to other factors. Let your prescriber know if you notice changes in your hearing in one or both ears while taking sildenafil (Revatio).
| Ingredient | Quantity per Tablet | Function | Notes |
|---|---|---|---|
| Sildenafil Citrate | 50 mg | Active ingredient | Main component |
| Microcrystalline Cellulose | 20 mg | Filler and binder | Increases tablet stability |
| Magnesium Stearate | 2 mg | Lubricant | Ensures smooth manufacturing |
| Starch | 10 mg | Diluent | Helps with disintegration |